San Francisco 49ers favorites over Colts 2010 NFL Preseason Predictions & Odds Week 1

49ers favorites over Colts 2010 NFL Preseason Picks & Odds Week 1 - Looking at the NFL Preseason Odds in this 2010 NFL Preseason Predictions matchup we see that the San Francisco 49ers are a -3.5 favorites. For all the "smart guys" who says the Colts will when easily or without Manning, if that were the case, they wouldn't have struggled with them last year when Manning tried 4 times to get into the endzone and couldn't.

If you are Betting On your NFL Preseason Odds with the Indianapolis Colts they are +3.5 +110 Underdogs at SPORTSBOOK.COM. The projected quarterback rotation for the 49ers as of now is Alex Smith, David Carr, Nate Davis and Jarrett Brown. San Francisco was 8-8 last season and looking to improve from a year ago.

The 49ers went 3-1 NFL Preseason Predictions under Mike Singletary last season, and given the coach’s fiery personality, it is no surprise that he wants to win every game they play, even if it's in the Pre-Season. No coach in football gives much effort every single game out then him, and that all starts by installing confidence by winning in August. recommendeds NFL Predictions on this game to bet on San Francisco 49ers.

Open up a Online Sportsbook account with SPORTSBOOK.COM to bet on NFL Preseason Odds now, as the NFL preseason Picks hits full stride this weekend and the NFL regular season is now just four weeks away!

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