New Orleans vs San Francisco Monday Night Football Picks, NFL Predictions & Vegas Betting Lines: The defending Super Bowl Champion New Orleans Saints (1-0) visit the San Francisco 49ers (0-1) on tonight's Monday Night Football picks contest during week two of the NFL predictions season in a NFC Conference Vegas NFL betting lines match-up. The Las Vegas odds makers have placed the visiting Saints as -6(-115) point NFL predictions favorites. From 2006 NFL picks season through 2008 NFL predictions season, the Saints and 49ers matched-up with New Orleans winning their NFL picks contests 34-10, 31-10, and 31-17 so the Las Vegas odds makers have reason to place the Saints as the Vegas NFL betting favorites.
The New Orleans Saints defeated the Vikings on opening night's NFL picks contest 14-9 in a hard-fought victory. Drew Brees, though he did not have staggering stats in the week 1 NFL predictions contest, was efficient enough against a tough Vikings defense. Marques Colston and Reggie Bush were the leading receivers and Pierre Thomas led the team in rushing.
The 49ers, meanwhile, were pounded in their opening NFL picks contest against Seattle 31-6. That lopsided NFL predictions loss will either spark the 49ers into playing a tough, emotional game at home on a Monday night or is a portent of things to come since the Saints are not the Seahawks.
Seattle’s Matt Hasselbeck was nearly perfect against the San Francisco secondary in their NFL predictions battle so look for Brees to throw the ball down the field in tonight's Monday Night Football picks contest. The 49ers could get no pressure on Hasselbeck and they will need to get in the face of Brees. If Brees is comfortable, New Orleans could put-up 40 points to take a week 2 NFL picks victory on Monday Night Football.
Alex Smith really struggled against Seattle in the 49ers last NFL predictions contest and the questions about his future as the San Francisco starting quarterback started again. Smith will need to be better against New Orleans and he will continue to lean on tight end Vernon Davis, and will need to get receivers Josh Morgan and Michael Crabtree involved as well. Frank Gore had difficulty running the ball and he might find tough sledding against the Saints.
The Saints, on the other hand, will bring a pressuring defense and a balanced offense into tonight's week 2 NFL picks match-up on Monday Night Football in San Francisco, and, like the three prior NFL predictions match-ups, the Saints should cover the Las Vegas betting line with ease.
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